Introduction: Human Metabolites in Safety Testing (MIST) Issue
نویسندگان
چکیده
منابع مشابه
Commentary SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING
Recent attention has been given to the potential roles that metabolites could play in safety evaluations of new drugs. In 2002, a proposal was published on “metabolites in safety testing” (“MIST”) [T. A. Baillie, M. N. Cayen, H. Fouda, R. J. Gerson, J. D. Green, S. J. Grossman, L. J. Klunk, B. LeBlanc, D. G. Perkins, and L. A. Shipley (2002) Toxicol Appl Pharmacol 182:188–196], which suggested ...
متن کاملSeeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing.
Recent attention has been given to the potential roles that metabolites could play in safety evaluations of new drugs. In 2002, a proposal was published on "metabolites in safety testing" ("MIST"), which suggested some guidelines regarding when it is necessary to provide greater assessment of the safety of metabolites. However, this proposal was based on relative abundance values, i.e., the per...
متن کاملFocus Issue on Metabolism: Metabolites, Metabolites Everywhere.
Metabolic studies have arguably been conducted since the 13th centurywith Ibn al-Nafis stating that “the body and its parts are in a continuous state of dissolution and nourishment, so they are inevitably undergoing permanent change” (Mahdi, 1974). However, it was studies in yeast in the last decades of the 19th century and the first decades of the 20th century (Kühne, 1877; Buchner, 1897; Sumn...
متن کاملIntroduction to Special Issue
Although recent frameworks for test validation have emphasized utilization as a key component (e.g. Bachman & Palmer, 2010; Chapelle, 2012; Kane, 1992), what happens in the sometimes messy contexts where assessments are carried out is often not documented. This is perhaps because test developers are more focused on defining and operationalizing test constructs than on issues of implementation. ...
متن کاملIntroduction to the Issue
Chile has usually been considered one of the outstanding countries in the World in terms of its record in reducing poverty. At the same time, income inequality in Chile remains high by international standards; in fact, cross-country comparisons places Chile amongst those countries with the highest dispersion of monetary income (World Bank 1997, 2001; Bravo and Contreras, 2004). This volume orig...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2009
ISSN: 0893-228X,1520-5010
DOI: 10.1021/tx900003k